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bumetanide-sensitive Na-K-2Cl cotransporter(165kDa、糖鎖3ケ)とthiazide-sensitive Na-Cl cotransporter (150kDa、糖鎖2ヶ)は類似の構造を持っている。両者は16染色体に存在している。イオンの結合部位と薬物の結合部位は不明である。*は糖鎖。(Am. J. Phyiol., 275, F325, 1998.)

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